Keon Coleman

With Keon Coleman (wrist) out, Samuel has seen increased usage in back-to-back weeks and made the most of his opportunities on Sunday against the Chiefs. Samuel's longest play was a 21-yard reception in the second quarter, but his biggest play came early in the fourth quarter when he found the end zone on a 12-yard touchdown to put the Bills up 23-14. Samuel's usage largely hinges on the return of Coleman, who could be back after the team's Week 12 bye to face the 49ers in Week 13. If Coleman is active, Samuel won't have any fantasy upside in that game.

Cooper will play through the wrist injury that has left him sidelined the last two weeks. The veteran receiver is expected to wear some sort of cast in Sunday's game, but said earlier in the week that he's gotten used to playing with it. Cooper profiles as a WR3 against a stout Chiefs defense. While he is active, the Bills did declare WR Keon Coleman, CB Kaiir Elam, LB Eddie Ulofoshio, OL Will Clapp, OT Spencer Brown, and TE Dalton Kincaid inactive fo Week 11.

Bills WR Amari Cooper (wrist) is listed as questionable for Sunday s game vs. the Chiefs after a limited week of practice. He said Thursday that he expected to play but would do so with a cast on his injured left wrist. Cooper would be a risky Week 11 fantasy start. WR Keon Coleman (wrist) has been ruled out for Week 11.

This news comes from head coach Sean McDermott, as the team has yet to release their Friday injury report. Cooper has been limited in practice throughout the week and hinted at playing on Thursday when asked about the possibility of suiting up. Assuming he's active, Cooper will profile as a volatile WR3. He's only appeared in one game for the Bills since being traded, but the absence of Keon Coleman (wrist) and Dalton Kincaid (knee) should give him some increased upside.

Having already ruled out receiver Keon Coleman, the Bills won't have a couple of other key players on the field as they begin their practice week.